I usually go by issue number, but in this case, the numbering was so confusing, I'm just going to not part numbers ... since that is the only distinctive thing on the title page that tells you where it falls in the order of things ... in case you were wondering why the sudden change here. Lol.
Part 1 of 6: The Lone Gunmen
At first, I was concerned that I was going to have a hard time understanding what was happening in these series, because I am not caught up on season 10, which this story is sort-of parallel to. However, after reading this issue, it feels like this is going to be it's own, completely separate story. I am sure it connects with all of the main series that are part of it, but I don't think you need to read the main series in order to read this, or vice versa.
I really enjoyed this issue. The characters were all well written, they sounded like themselves without sounding like caricatures of themselves (which I have seen in past crossovers). I was very happy to see Mulder and Scully more than fleetingly involved in this issue. They've got the Lone Gunmen on the mission, or rather, the Gunmen are on the mission, and they are keeping Mulder and Scully posted.
I'm loving the danger and the variety in this story already. All of these universes coming into one is really special. It's almost fanfiction. See kids, keep telling those stories, people will listen and they will become cannon someday.